ZyMōt

What is ZyMōt?

The ZyMōt Multi Sperm Separation Device, commonly referred to as a sperm sorting chip, is a tool which prepares motile sperm for reproductive technology procedures. The device mimics how sperm naturally travel through the female reproductive system and separates the best quality sperm which can be used for treatment. This is achieved by sperm moving through a membrane filter embedded in the chip. Studies suggest this device isolates progressively motile sperm with less DNA fragmentation.

What is sperm preparation and why do we do it?

Sperm preparation is a crucial step in assisted reproductive treatments to ensure that the best quality sperm is used. This process involves processing the sperm sample to remove any debris, dead sperm, and other cells, leaving behind the most motile (active) and healthy sperm. This is important because using high-quality sperm can increase the chances of successful fertilisation and embryo development.

How does ZyMōt work?

ZyMōt is a sperm-separation device designed to select the healthiest sperm for use in fertility treatments. It works by passing a semen sample through a special filter that separates the most motile (active) sperm from the rest. Here’s a simplified breakdown:

The semen sample is placed into the lower chamber of the ZyMōt device.

The sperm move through a microporous filter to reach the upper chamber.

Only the most active sperm can navigate through the filter into the upper chamber.

The selected, highly motile sperm are collected from the upper chamber for use in assisted reproductive treatments.

Why is sperm DNA important and what is DNA fragmentation?

The sperm cell transports half of the genetic material necessary to fuse with the egg, forming the genetic blueprint for the offspring. This combined DNA contains the essential instructions for embryo development. Any damage to this genetic code can hinder the sperm’s ability to successfully fertilise the egg or support the formation of a healthy embryo.

Sperm DNA fragmentation refers to the damage and breaks in the genetic material. This damage is commonly caused by Reactive Oxygen Species (ROS) which are naturally occurring molecules produced within the cells. Some people may have high sperm DNA fragmentation which can be tested for using a DNA fragmentation test. Some research suggests that other sperm preparation methods may increase DNA fragmentation while the ZyMōt device aims to reduce this.

For more info on DNA fragmentation please visit: https://www.fertilitybristol.c...

Why does high DNA fragmentation matter?

It is important to note that conception is still possible for those with high sperm DNA fragmentation. However, studies have shown that individuals with high levels of sperm DNA fragmentation may experience lower pregnancy rates, longer time to conception, or higher miscarriage rates. In patients undergoing fertility treatment, high levels of DNA fragmentation in sperm can negatively impact early embryo development, potentially affecting the success of assisted reproductive procedures.

Who is ZyMōt suitable for?

The ZyMōt Multi Sperm Separation device will be included as part of your treatment cycle and is suitable for a variety of assisted reproductive procedures with fresh or frozen samples, including:

Intracytoplasmic sperm injection (ICSI).

Intrauterine insemination (IUI).

In vitro fertilisation (IVF).

Limitations of ZyMōt:

While ZyMōt offers advanced sperm sorting capabilities, it may not be suitable for all cases. The ZyMōt Multi-device requires a minimum of 1 million progressively motile sperm per ml for treatment.

To find out more contact the laboratory on Lab@BCRM.clinic or download the ZyMōt Patient Information leaflet

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